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Nephron prorenin receptor deficiency alters renal medullary endothelin-1 and endothelin receptor expression
The endothelin (ET) and prorenin/renin/prorenin receptor (PRR) systems have opposing physiological effects on collecting duct (CD) salt and water reabsorption. It is unknown if the CD ET and renin/PRR systems interact, hence we examined the effects of deleting CD renin or nephron PRR on CD ET system components. PRR knockout (KO) mice were polyuric and had markedly increased urinary ET-1 and inner …
Creator
- Ramkumar, N.
- Stuart, D.
- Kohan, D. E.
- Abraham, N.
Subject
- fyziologie člověka
- human physiology
- Endothelin
- Prorenin
- Collecting duct
- Knockout
- Receptor
- 14
- 612
Type of item
- model:article
Creator
- Ramkumar, N.
- Stuart, D.
- Kohan, D. E.
- Abraham, N.
Subject
- fyziologie člověka
- human physiology
- Endothelin
- Prorenin
- Collecting duct
- Knockout
- Receptor
- 14
- 612
Type of item
- model:article
Providing institution
Aggregator
Rights statement for the media in this item (unless otherwise specified)
- http://creativecommons.org/publicdomain/mark/1.0/
Rights
- policy:public
Source
- Physiological research | 2018 Volume:67 | Number:Suppl 1
Identifier
- uuid:ae1a6256-ccb6-4f5e-a8c0-b84fcc269109
- https://cdk.lib.cas.cz/client/handle/uuid:ae1a6256-ccb6-4f5e-a8c0-b84fcc269109
- uuid:ae1a6256-ccb6-4f5e-a8c0-b84fcc269109
- issn:0862-8408
Format
- bez média
- svazek
Language
- eng
- eng
Providing country
- Czech Republic
Collection name
First time published on Europeana
- 2021-06-01T12:19:28.026Z
Last time updated from providing institution
- 2021-06-01T12:19:28.026Z